M. Snyder

Oxidative Stress is a shared characteristic of ME/CFS and Long COVID

This study identifies elevated oxidative stress in both ME/CFS and Long COVID patients through blood cell analysis, suggesting shared molecular mechanisms and potential therapeutic targets.

Population genetic analyses of longitudinal vaginal microbiome reveal racioethnic evolutionary dynamics and prevailing positive selection of Lactobacillus adhesins

This study analyzes longitudinal vaginal microbiome data from diverse ethnic groups, revealing ethnic signatures in microbial diversity, community states, and evolutionary dynamics, with Lactobacillus adhesins showing positive selection.

Integrated platform for multi-scale molecular imaging and phenotyping of the human brain

The paper develops a platform for multi-scale molecular imaging and phenotyping of the human brain, integrating novel tools for tissue processing, imaging, and computational reconstruction.

Wireless closed-loop smart bandage for chronic wound management and accelerated tissue regeneration

This paper develops a wireless smart bandage that monitors wound conditions and delivers electrical stimulation to accelerate tissue regeneration in chronic wounds.

An acetyl-click screening platform identifies a small molecule inhibitor of Histone Acetyltransferase 1 (HAT1) with anti-tumor activity

This paper identifies a small molecule inhibitor of HAT1, a histone acetyltransferase, showing anti-tumor activity in vitro and in vivo.

Cell-free DNA (cfDNA) and exosome profiling from a year-long humanspaceflight reveals circulating biomarkers

This study profiles cfDNA and exosomes from an astronaut during a year-long spaceflight, identifying increased cf-mtDNA and exosomal brain-derived peptides as potential biomarkers of spaceflight-related stress.

Global analysis of epigenetic heterogeneity identifies divergent drivers of esophageal squamous cell carcinoma

The paper identifies epigenetic drivers of esophageal squamous cell carcinoma through multi-omics analysis, revealing hypomethylation patterns and non-canonical WNT signaling activation.

MISTERMINATE Mechanistically Links Mitochondrial Dysfunction with Proteostasis Failure

The paper identifies MISTERMINATE as a mechanism linking mitochondrial dysfunction to proteostasis failure through translational termination impairment and C-terminal extension of mitochondrial proteins.

Classifying Non-Small Cell Lung Cancer Histopathology Types and Transcriptomic Subtypes using Convolutional Neural Networks

This study uses convolutional neural networks to classify non-small cell lung cancer histopathology types and transcriptomic subtypes using whole-slide images from The Cancer Genome Atlas.

Genome wide association with quantitative resistance phenotypes in Mycobacterium tuberculosis reveals novel resistance genes and regulatory regions

This study identifies novel resistance genes and regulatory regions in Mycobacterium tuberculosis using genome-wide association analysis of drug resistance phenotypes.