Mutability of mononucleotide repeats, not oxidative stress, explains the discrepancy between laboratory-accumulated mutations and the natural allele-frequency spectrum in C. elegans
M. Rajaei, A. S. Saxena, L. M. Johnson, M. C. Snyder, T. A. Crombie, R. E. Tanny, E. C. Andersen, J. Joyner-Matos, C. F. Baer
The study shows that differences in mutation spectra between lab and natural C. elegans populations are due to mononucleotide repeat mutability, not oxidative stress.
bioRxiv · Feb 9, 2021Evolutionary Biology