Author

T. A. Crombie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Ecology· 3 Evolutionary Biology· 3 Bioengineering· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 7 Approach:experimental assay· 4 Approach:statistical model· 4 Research Focus:chromatin & epigenetic regulation· 3 Assay:whole-genome sequencing· 3 Research Focus:benchmarking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

E. C. Andersen· 5 shared D. E. Cook· 4 shared R. E. Tanny· 4 shared D. Lee· 3 shared K. S. Evans· 3 shared S. Zdraljevic· 3 shared A. S. Saxena· 2 shared C. F. Baer· 2 shared

Activity by Year

2018-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersEcology

E. C. Andersen

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Author profile →

8 papers

Recent·Most cited

C. elegans toxicant responses vary among genetically diverse individuals

S. J. Widmayer, T. A. Crombie, J. Nyaanga, K. S. Evans, E. C. Andersen

This study shows that genetic diversity in C. elegans strains leads to varying toxicant responses, highlighting the need for genetically diverse strains in toxicological screening.

Toxicology · Sep 1, 2022Peer-reviewedPharmacology & Toxicology

High-throughput imaging of Caenorhabditis elegans aging using collective activity monitoring

A. D. Fouad, M. A. Churgin, J. Hayden, J. Xu, J.-I. Park, A. Liu, C. Teng, H. Sun, M. Parrado, P. Bowlin, M. de la Torre, T. A. Crombie, C. Sedore, A. L. Coleman-Hulbert, E. Johnson, , C. Fang-Yen

The paper introduces WormCamp, a high-throughput system for aging research in C. elegans, showing it can estimate lifespan and healthspan through collective activity monitoring.

bioRxiv · Oct 18, 2021 · PreprintBioengineering

Local adaptation and spatiotemporal patterns of genetic diversity revealed by repeated sampling of Caenorhabditis elegans across the Hawaiian Islands

T. A. Crombie, P. Battlay, R. E. Tanny, K. S. Evans, C. M. Buchanan, D. E. Cook, C. M. Dilks, L. A. Stinson, S. Zdraljevic, G. Zhang, N. M. Roberto, D. Lee, M. Ailion, K. A. Hodgins, E. C. Andersen

This study samples C. elegans across Hawaii over three years, sequenced their genomes, and found seven genetic groups and 18 regions linked to local adaptation.

bioRxiv · Oct 11, 2021Ecology

easyFulcrum: An R package to process and analyze ecological sampling data generated using the Fulcrum mobile application

T. A. Crombie, M. Di Bernardo, D. E. Cook, E. Andersen

The paper introduces easyFulcrum, an R package that processes and analyzes ecological sampling data from the Fulcrum mobile app, improving data accuracy and integration for microscopic organisms.

bioRxiv · Jun 20, 2021Ecology

Mutability of mononucleotide repeats, not oxidative stress, explains the discrepancy between laboratory-accumulated mutations and the natural allele-frequency spectrum in C. elegans

M. Rajaei, A. S. Saxena, L. M. Johnson, M. C. Snyder, T. A. Crombie, R. E. Tanny, E. C. Andersen, J. Joyner-Matos, C. F. Baer

The study shows that differences in mutation spectra between lab and natural C. elegans populations are due to mononucleotide repeat mutability, not oxidative stress.

bioRxiv · Feb 9, 2021Evolutionary Biology

Balancing selection maintains hyper-divergent haplotypes in C. elegans

D. Lee, S. Zdraljevic, L. Stevens, Y. Wang, R. E. Tanny, T. A. Crombie, D. E. Cook, A. K. Webster, R. Chirakar, L. R. Baugh, M. Sterken, C. Braendle, M.-A. Felix, M. Rockman, E. C. Andersen

The paper shows that balancing selection maintains genetic diversity in hyper-divergent regions of C. elegans, enabling adaptation despite selfing.

bioRxiv · Jul 23, 2020 · PreprintEvolutionary Biology

Deep sampling of Hawaiian Caenorhabditis elegans reveals high genetic diversity and admixture with global populations

T. A. Crombie, S. Zdraljevic, D. E. Cook, R. E. Tanny, S. C. Brady, Y. Wang, K. S. Evans, S. Hahnel, D. Lee, B. C. Rodriguez, G. Zhang, J. van der Zwaag, K. C. Kiontke, E. C. Andersen

The paper samples Hawaiian C. elegans strains, revealing high genetic diversity and admixture with global populations, suggesting ancestral diversity preserved in Hawaii.

bioRxiv · Jul 28, 2019Ecology

Head-to-Head Comparison of Three Methods of Quantifying Competitive Fitness in C. elegans

T. A. Crombie, S. Saber, A. S. Saxena, R. Egan, C. F. Baer

The paper compares three methods for quantifying competitive fitness in C. elegans, finding no significant differences in results but highlighting increased speed with automated tools.

bioRxiv · Jul 18, 2018Evolutionary Biology