C. F. Baer

Direct inference of the distribution of fitness effects of spontaneous mutations from recombinant inbred C. elegans mutation accumulation lines

This study infers the distribution of fitness effects of mutations in C. elegans using recombinant inbred lines, finding that positive effects are common but LD can skew results.

Phenotypic stasis with genetic divergence

The paper evolves Caenorhabditis elegans populations for 240 generations and finds phenotypic stasis in locomotion behavior despite genetic divergence.

Variation in mutational (co)variances

The paper estimates the M matrix for locomotion traits in two C. elegans genotypes and finds similar mutational variances but differences from a lab-adapted G matrix due to linkage disequilibrium.

Cumulative effects of mutation and selection on susceptibility to bacterial pathogens in Caenorhabditis elegans

The paper examines how mutations and selection affect pathogen susceptibility in C. elegans, finding mutations increase susceptibility and selection acts on it, but no fitness tradeoffs are observed.

Mutability of mononucleotide repeats, not oxidative stress, explains the discrepancy between laboratory-accumulated mutations and the natural allele-frequency spectrum in C. elegans

The study shows that differences in mutation spectra between lab and natural C. elegans populations are due to mononucleotide repeat mutability, not oxidative stress.

The distribution of mutational effects on fitness in Caenorhabditis elegans inferred from standing genetic variation

This study estimates the distribution of fitness effects from standing genetic variation in C. elegans and shows how self-fertilization and population structure bias DFE inferences.

Reverse plasticity underlies rapid evolution by clonal selection within populations of fibroblastspropagated on a novel soft substrate

This study shows that reverse plasticity drives rapid evolution in fibroblasts adapted to soft substrates through genetic changes, not phenotypic plasticity alone.

Short-term heritable variation overwhelms two hundred generations of mutational variance for metabolic traits in Caenorhabditis elegans

The paper quantifies short-term heritable variation in metabolic traits of C. elegans and finds it comparable to mutational variance, suggesting epigenetic factors may significantly contribute to metabolic disease heritability.

Selection and drift determine phenotypic stasis despite genetic divergence

The paper shows phenotypic stasis in C. elegans despite genetic divergence, due to stabilizing and disruptive selection, with genetic variance-covariance structure changes explained by selection and drift.

Evolution of the mutational process under relaxed selection in Caenorhabditis elegans

This study examines mutation rate variation in Caenorhabditis elegans mutation accumulation lines, finding that base-substitution rates vary with recombination and GC content, while indel rates are higher in high-fitness lines.

Head-to-Head Comparison of Three Methods of Quantifying Competitive Fitness in C. elegans

The paper compares three methods for quantifying competitive fitness in C. elegans, finding no significant differences in results but highlighting increased speed with automated tools.

The mutational decay of male and hermaphrodite competitive fitness in the androdioecious nematode C. elegans, in which males are naturally rare

The paper estimates mutational effects on male and hermaphrodite competitive fitness in C. elegans, finding males decay faster due to higher mutation rates and mating variability.