J. K. Claridge

Menin regulates androgen receptor- and MLL-driven condensation, upsetting regulation of cellular AR-driven transcription.

This study shows menin regulates AR and MLL-driven RNA condensates through dimerization, affecting transcription regulation and contributing to cancer when disrupted.

The folding-limited nucleation of curli hints at an evolved safety mechanism for functional amyloid production

This study investigates the molecular mechanism of curli amyloid formation in Salmonella and Escherichia coli, revealing a folding-limited nucleation process that balances efficient polymerization with avoiding premature aggregation.

Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza

The paper identifies M2-N31 inhibitors that show synergistic antiviral effects when combined with existing drugs, offering a strategy to combat rimantadine-resistant influenza.