Author

S. Griffin

National Oceanic and Atmospheric Administration

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2 Bioengineering· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Approach:statistical model· 2 Organism:Arabidopsis· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

C. S. McKimmie· 3 shared A. Macdonald· 2 shared A. Samson· 2 shared C. Scott· 2 shared G. P. Cook· 2 shared J. Kankanala· 2 shared M. J. Bentham· 2 shared M. Pingen· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

C. S. McKimmie

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

IFNB induced by non-lytic virus immunotherapy promotes improved survival in hepatocellular carcinoma, mediated by MHCII-independent cytotoxic CD4+ T-cells

R. Hughes, A. Moran, K. J. Scott, E. Appleton, M. J. Bentham, E. Ilett, A. Melcher, A. Macdonald, A. Samson, S. Griffin

This paper shows that uv-inactivated reovirus combined with sorafenib improves survival in HCC by promoting IFNβ-induced cytotoxic CD4+ T-cell responses that are MHCII-independent.

bioRxiv · Feb 23, 2024 · PreprintImmunology

Lung Tumor Microphysiological System with 3D Endothelium to Evaluate Modulators of T-Cell Infiltration

K. M. Wisdom, J. Suijker, L. van den Broek, B. Sridharan, T. S. P. Grandhi, A. Cheng, M. Lamb, S. A. Titus, A. Gehman, D. Poore, N. Shah, S.-H. Cheng, E. Kim, S. Griffin, J. Ekert

This paper introduces a 3D lung tumor on chip model with endothelium to evaluate T-cell infiltration modulators and demonstrates its utility in assessing immune chemotaxis and vascular responses.

bioRxiv · Aug 3, 2022 · PreprintBioengineering

Mosquito saliva sialokinin-dependent enhancement of arbovirus infection through endothelial barrier leakage

D. Lefteri, S. Bryden, M. Pingen, S. Terry, E. Beswick, G. Georgiev, M. Van Der Laan, V. Mastrullo, P. Campagnolo, R. M. Waterhouse, M. Varjak, A. Merits, R. Fragkoudis, S. Griffin, E. Pondeville, C. S. McKimmie

This study identifies sialokinin in Aedes mosquito saliva as a factor that enhances arbovirus infection by reducing endothelial barrier integrity, suggesting it as a therapeutic target.

bioRxiv · Feb 19, 2021Microbiology

The CXCR6/CXCL16 axis links inflamm-aging to disease severity in COVID-19 patients

D. J. Payne, S. Dalal, R. Leach, R. Parker, S. Griffin, C. S. McKimmie, G. P. Cook, S. J. Richards, P. Hillmen, T. Munir, L. Arnold, K. Riley, C. McKinley, S. Place, R. L. Baretto, D. J. Newton

This study examines the role of the CXCR6/CXCL16 axis in severe COVID-19, finding elevated CD8+CXCR6+ T cells with age and increased CXCL16 levels in severe cases.

bioRxiv · Jan 25, 2021 · PreprintImmunology

STAGdb: a 30K SNP genotyping array and Science Gateway for Acropora corals and their dinoflagellate symbionts

Sheila A. Kitchen, Gregory Von Kuster, Kate L. Vasquez Kuntz, Hannah G. Reich, Webb Miller, S. Griffin, Nicole D. Fogarty, Iliana B. Baums

The paper develops a SNP genotyping array and analysis workflow for Acropora corals and their symbionts, enabling genotype identification and ancestry analysis.

Scientific Reports · Jul 27, 2020Peer-reviewedGenetics

Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

J. Shaw, R. Gosein, M. M. Kalita, J. Kankanala, D. R. Mahato, T. Foster, C. Scott, E. Brown, B. J. King, M. Bentham, L. Wetherill, A. Bloy, A. Samson, M. Harris, J. Mankouri, , S. Griffin

The paper designs a rationally derived inhibitor of HCV p7 channel activity, revealing its dual role in virus entry and infection spread, and highlights its potential for bimodal antiviral therapy.

bioRxiv · Oct 7, 2019Microbiology

Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza

C. Scott, J. Kankanala, T. L. Foster, D. Goldhill, K. J. Simmons, M. Pingen, M. J. Bentham, E. Atkins, E.-A. Loundras, R. Elderfield, J. K. Claridge, J. Thompson, R. Stilwell, R. Tathineni, C. S. McKimmie, , S. Griffin

The paper identifies M2-N31 inhibitors that show synergistic antiviral effects when combined with existing drugs, offering a strategy to combat rimantadine-resistant influenza.

bioRxiv · Jul 24, 2019Microbiology