Sustained post-developmental T-bet expression is critical for the maintenance of type 1 innate lymphoid cells in vivo
J.-H. Schroeder, L. B. Roberts, K. Meissl, J. W. Lo, D. Hromadova, K. Hayes, T. Zabinski, E. Read, C. Moreira Heliodoro, R. Reis, J. K. Howard, R. K. Grencis, J. F. Neves, B. Strobl, G. M. Lord
This study shows that sustained T-bet expression is necessary for maintaining intestinal ILC1 in vivo, and ILC1 depletion protects against colitis, suggesting potential therapeutic targeting of T-bet for IBD treatment.
bioRxiv · Jun 5, 2021Immunology