Cohesin-independent STAG proteins interact with RNA and localise to R-loops to promote complex loading.
H. Porter, Y. Li, W. Varsally, M. V. Neguembor, M. Beltran, D. Pezic, L. Martin, M. Tavares Cornejo, A. Bhamra, S. Surinova, R. G. Jenner, M. P. Cosma, S. HADJUR
The paper shows SA proteins interact with RNA and R-loops to promote cohesin loading independently of NIPBL, revealing a new role in chromatin structure and cancer biology.
bioRxiv · Feb 20, 2021Cell Biology