Author

J. K. Shanahan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Organism:human· 1 Organism:zebrafish· 1

Frequent Co-Authors

A. J. Pagan· 2 shared L. Ramakrishnan· 2 shared M. M. Osman· 2 shared F. Chu· 1 shared K. Takaki· 1 shared M. Pinckert· 1 shared R. Brosch· 1 shared W. Conrad· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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2 shared papersMicrobiology

A. J. Pagan

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2 papers

Recent·Most cited

MicrobiologybioRxivJan 14, 2022

The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence

M. M. Osman, J. K. Shanahan, F. Chu…·L. Ramakrishnan

This paper identifies conserved residues in the C-terminal tail of ESAT-6 required for phagosomal damage and virulence, while showing that secretion levels remain near-normal in these mutants.

DOI 10.1073/pnas.2122161119

mousehuman

𝕏 PostBluesky

MicrobiologybioRxivMay 4, 2020

Mycobacterium marinum phthiocerol dimycocerosates enhance macrophage phagosomal permeabilization and membrane damage

M. M. Osman, L. Ramakrishnan, A. J. Pagan, J. K. Shanahan

This study shows PDIMs in M. marinum enhance phagosomal membrane damage and hemolysis, with PDIM mutants retaining more membrane-damaging activity than ESX-1 mutants.

DOI 10.1371/journal.pone.0233252

mousezebrafish

𝕏 PostBluesky