Author

M. M. Osman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

L. Ramakrishnan· 3 shared A. J. Pagan· 2 shared J. K. Shanahan· 2 shared F. Chu· 1 shared K. Takaki· 1 shared M. A. Troll· 1 shared M. L. Pinckert· 1 shared M. Pinckert· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

L. Ramakrishnan

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence

M. M. Osman, J. K. Shanahan, F. Chu, K. Takaki, M. Pinckert, A. J. Pagan, R. Brosch, W. Conrad, L. Ramakrishnan

This paper identifies conserved residues in the C-terminal tail of ESAT-6 required for phagosomal damage and virulence, while showing that secretion levels remain near-normal in these mutants.

bioRxiv · Jan 14, 2022Microbiology

Ebselen attenuates mycobacterial virulence through inhibition of ESX-1 secretion

M. M. Osman, M. L. Pinckert, S. Peak-Chew, M. A. Troll, W. H. Conrad, L. Ramakrishnan

This paper shows ebselen inhibits ESX-1 secretion in M. marinum and M. tuberculosis, reducing virulence and intracellular growth.

bioRxiv · Dec 13, 2021 · PreprintMicrobiology

Mycobacterium marinum phthiocerol dimycocerosates enhance macrophage phagosomal permeabilization and membrane damage

M. M. Osman, L. Ramakrishnan, A. J. Pagan, J. K. Shanahan

This study shows PDIMs in M. marinum enhance phagosomal membrane damage and hemolysis, with PDIM mutants retaining more membrane-damaging activity than ESX-1 mutants.

bioRxiv · May 4, 2020Microbiology