J. Kere

Transient DUX4 expression induces blastomere-like expression program that is marked by SLC34A2

The paper shows that transient DUX4 expression in hESCs generates iBM cells with EGA-like profiles, resembling 8-cell blastomeres and can be enriched using SLC34A2.

Ectopic histone clipping in the mouse model of progressive myoclonus epilepsy

This study identifies CSTB as a regulator of histone H3 tail clipping in NPCs and links its deficiency to epigenetic dysregulation and impaired mitochondrial function in a mouse model of progressive myoclonus epilepsy.

Balancing Selection at HLA-G Modulates Fetal Survival, Preeclampsia and Human Birth Sex Ratio

The paper investigates the role of HLA-G genetic variation in fetal survival, preeclampsia, and human sex ratio, finding balancing selection influences these outcomes.

Single cell map of the human ovarian cortex.

This study maps the single-cell transcriptome and surface antigens of ovarian cortex cells, revealing six main cell types and showing DDX4 captures perivascular cells, not oogonial stem cells, supporting a limited ovarian reserve.

Characterization of novel TMEM173 mutation with additive IFIH1 risk allele

The paper reports a novel gain-of-function TMEM173 mutation and its additive effects with IFIH1 risk allele on clinical phenotype in a multigeneration family.

Human pluripotent reprogramming with CRISPR activators

This study reprograms human skin fibroblasts into iPSC using CRISPRa, showing that targeting an Alu-motif enhances reprogramming efficiency by improving activation of NANOG and REX1.