M. Varjosalo

Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells

This study shows that KEAP1 mutations in lung cancer activate TRAF2-NFκB signaling, enhancing cell survival by preventing apoptosis.

Small mitochondrial protein NERCLIN regulates cardiolipin homeostasis and mitochondrial ultrastructure.

This study identifies NERCLIN as a mitochondrial protein that regulates cardiolipin homeostasis and ultrastructure, with implications for stress-induced mitochondrial adaptation.

GTPBP8 is required for mitoribosomal biogenesis and mitochondrial translation

This study identifies GTPBP8 as a critical factor for mitoribosomal assembly and mitochondrial translation, showing its depletion impairs subunit maturation and function.

Structure and Interactions of the Endogenous Human Commander Complex

This study determines the structure of the endogenous human Commander complex using cryo-EM and proteomics, revealing its asymmetric organization and novel interactions involved in cellular processes.

Parvovirus infection affects host cell nucleolar organization and ribosome biogenesis

This study investigates how canine parvovirus infection alters nucleolar structure and ribosome biogenesis using advanced imaging and biochemical techniques.

Transient DUX4 expression induces blastomere-like expression program that is marked by SLC34A2

The paper shows that transient DUX4 expression in hESCs generates iBM cells with EGA-like profiles, resembling 8-cell blastomeres and can be enriched using SLC34A2.

PROX1 transcription factor is a master regulator of myogenic and oncogenic features of rhabdomyosarcoma

This study identifies PROX1 as a master regulator of myogenic and oncogenic features in rhabdomyosarcoma, showing its role in stemness, tumor growth, and therapeutic potential through HDAC interactions.

Pharmacologically diverse antidepressant drugs disrupt the interaction of BDNF receptor TRKB and the endocytic adaptor AP-2

This study shows that multiple antidepressants disrupt the TRKB:AP2M interaction, affecting TRKB surface expression and BDNF signaling.

Tissue-ABPP enables high-resolution confocal fluorescence imaging of serine hydrolase activity in cryosections - Application to glioma brain unveils activity hotspots originating from tumor-associated neutrophils

The paper introduces tissue-ABPP, a method for high-resolution imaging of serine hydrolase activity in tissue sections, revealing activity hotspots in glioma tumors linked to neutrophils.

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing

The paper identifies novel nuclear actin binding partners and functional roles in chromatin remodeling, transcription, and RNA splicing using mass spectrometry techniques.

FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis

This study identifies FGFR4 as a kinase that phosphorylates MST1, thereby inhibiting MST1/2-dependent apoptosis and promoting breast cancer cell survival.

Characterization of novel TMEM173 mutation with additive IFIH1 risk allele

The paper reports a novel gain-of-function TMEM173 mutation and its additive effects with IFIH1 risk allele on clinical phenotype in a multigeneration family.

Systems pathology analysis identifies neurodegenerative nature of age-related retinal diseases

The paper uses proteomics to analyze age-related retinal diseases, identifying inflammation and neurodegeneration as key factors in their pathogenesis.