In silico APC/C substrate discovery reveals cell cycle degradation of chromatin regulators including UHRF1
J. Kernan, R. C. Martinez-Chacin, X. Wang, R. L. Tiedemann, T. Bonacci, R. Choudhury, D. Bolhuis, J. S. Damrauer, F. Yan, J. S. Harrison, M. B. Major, K. Hoadley, A. Suzuki, S. B. Rothbart, N. G. Brown, M. J. Emanuele
The paper predicts APC/C substrates in silico, identifies chromatin regulators as substrates, and shows their cell cycle-dependent degradation and impact on DNA methylation.
bioRxiv · Apr 9, 2020Cell Biology