Author

M. J. Emanuele

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

N. G. Brown· 2 shared T. P. Enrico· 2 shared X. Wang· 2 shared A. C. Raimer· 1 shared A. D. Ebert· 1 shared A. G. Matera· 1 shared A. I. Lamond· 1 shared A. M. Spring· 1 shared

Activity by Year

2016-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCell Biology

N. G. Brown

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Adaptive IRE1 Signaling Elicits T Cell Metabolic Remodeling and Tumor Control

B. P. Riesenberg, E. J. Gandy, A. S. Kennedy, E. G. Hunt, K. E. Hurst, E. L. Sedlacek, P. Gao, M. J. Emanuele, J. Modliszewski, J. M. Green, J. J. Milner, L. Wiseman, J. E. Thaxton

This study shows that enhancing the adaptive IRE1 UPR pathway in T cells improves tumor control by reducing mitochondrial toxicity and chronic ER stress.

bioRxiv · Nov 16, 2023 · PreprintImmunology

Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2

T. P. Enrico, W. Stallaert, E. T. Wick, P. Ngoi, S. M. Rubin, N. G. Brown, J. E. Purvis, M. J. Emanuele

This study identifies cyclin F as a regulator of p130/RBL2 degradation via SCF, showing its role in cell cycle control and potential implications in cancer.

bioRxiv · Apr 23, 2021Cell Biology

In silico APC/C substrate discovery reveals cell cycle degradation of chromatin regulators including UHRF1

J. Kernan, R. C. Martinez-Chacin, X. Wang, R. L. Tiedemann, T. Bonacci, R. Choudhury, D. Bolhuis, J. S. Damrauer, F. Yan, J. S. Harrison, M. B. Major, K. Hoadley, A. Suzuki, S. B. Rothbart, N. G. Brown, M. J. Emanuele

The paper predicts APC/C substrates in silico, identifies chromatin regulators as substrates, and shows their cell cycle-dependent degradation and impact on DNA methylation.

bioRxiv · Apr 9, 2020Cell Biology

Cell cycle oscillators underlying orderly proteolysis of E2F8

D. Wasserman, S. Nachum, M. Cohen, T. P. Enrico, M. Noach-Hirsh, J. Parasol, S. Zomer-Polak, N. Auerbach, E. Sheinberger-Chorni, H. Nevenzal, N. Levi-Dadon, X. Wang, R. Lahmi, E. Michaely, D. Gerber, , A. Tzur

The paper investigates the mechanisms controlling E2F8 dynamics during the cell cycle using cell-free systems, revealing phosphorylation, ubiquitination, and transcriptional regulation.

bioRxiv · Jun 16, 2019Cell Biology

Self-oligomerization regulates stability of Survival Motor Neuron (SMN) protein isoforms by sequestering an SCFSlmb degron

K. M. Gray, K. A. Kaifer, D. Baillat, Y. Wen, T. R. Bonacci, A. D. Ebert, A. C. Raimer, A. M. Spring, S. ten Have, J. J. Glascock, K. Gupta, G. D. Van Duyne, M. J. Emanuele, A. I. Lamond, E. J. Wagner, , A. G. Matera

The paper identifies SCFSlmb as a regulator of SMN protein stability through a degron, showing that self-oligomerization stabilizes SMN isoforms and mitigates SMA severity.

bioRxiv · Sep 30, 2016Biochemistry