Poly(A)-binding protein is an ataxin-2 chaperone that emulsifies biomolecular condensates.
S. Boeynaems, Y. Dorone, A. Marian, V. Shabardina, G. Huang, G. Kim, A. Sanyal, N.-E. Sen, R. Docampo, I. Ruiz-Trillo, K. Lasker, G. Auburger, E. Kabashi, A. D. Gitler
The paper identifies a conserved 14aa sequence in ataxin-2 that acts as a condensation switch and reveals poly(A)-binding proteins as RNA-dependent chaperones that regulate this switch.
bioRxiv · Aug 23, 2021 · PreprintCell Biology