KappaBle fluorescent reporter mice enable dynamic and low-background single-cell detection of NF-kB activity in vivo
L. Tortola, F. Ampenberger, E. Rosenwald, S. Heer, T. Ruelicke, J. Kisielow, M. Kopf
The paper develops KappaBle mice with a destabilized EGFP reporter to sensitively and dynamically monitor NF-kB activity at the single-cell level in vivo during inflammation and infection.
bioRxiv · Sep 2, 2021 · PreprintImmunology