F. Ampenberger

KappaBle fluorescent reporter mice enable dynamic and low-background single-cell detection of NF-kB activity in vivo

The paper develops KappaBle mice with a destabilized EGFP reporter to sensitively and dynamically monitor NF-kB activity at the single-cell level in vivo during inflammation and infection.

Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing

This study identifies Rnf31 and Vps4b as factors enabling pancreatic cancer to evade T cell killing, showing their inactivation increases T cell-mediated tumor cell death.