Author

T. Ruelicke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Animal Behavior & Cognition· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Assay:behavioral assay· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

B. Maurer· 2 shared G. Hoermann· 2 shared R. Moriggl· 2 shared A. Boersma· 1 shared A. Hiesinger· 1 shared A. Pichler· 1 shared A. T. Look· 1 shared A. Witalisz-Siepracka· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCancer Biology

B. Maurer

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A lineage-specific STAT5BN642H mouse model to study NK-cell leukemia

K. Klein, S. Kollmann, J. List, A. Hiesinger, J. Kender, M. Rhandawa, J. Trifinopoulos, B. Maurer, R. Grausenburger, R. Moriggl, T. Ruelicke, A. Witalisz-Siepracka, W. Walter, G. Hoermann, V. Sexl, D. Gotthardt

This paper creates a mouse model with a STAT5BN642H mutation to study NK-cell leukemia and finds it leads to both indolent and aggressive forms of the disease.

Blood · Jun 13, 2024Peer-reviewedCancer Biology

STAT5 Gain-of-Function Variants Promote Precursor T-Cell Receptor Activation to Drive T-Cell Acute Lymphoblastic Leukemia

T. Suske, H. Sorger, F. Ruge, N. Prutsch, M. W. Zimmerman, T. Eder, B. Maurer, C. Wagner, S. Schoenefeldt, K. Spirk, A. Pichler, T. Pemovska, C. Schweicker, D. Poeloeske, D. Jungherz, , R. Moriggl

This study identifies STAT5 gain-of-function mutations as drivers of T-ALL by promoting pre-TCR signaling and shows therapeutic targeting potential with STAT3/5 or ZAP70 inhibitors.

bioRxiv · Dec 21, 2022 · PreprintCancer Biology

KappaBle fluorescent reporter mice enable dynamic and low-background single-cell detection of NF-kB activity in vivo

L. Tortola, F. Ampenberger, E. Rosenwald, S. Heer, T. Ruelicke, J. Kisielow, M. Kopf

The paper develops KappaBle mice with a destabilized EGFP reporter to sensitively and dynamically monitor NF-kB activity at the single-cell level in vivo during inflammation and infection.

bioRxiv · Sep 2, 2021 · PreprintImmunology

Essential role of the mouse synapse associated protein Syap1 in circuits for spontaneous motor activity and rotarod balance

C. R. von Collenberg, D. Schmitt, T. Ruelicke, M. Sendtner, R. Blum, E. Buchner

This study investigates the role of Syap1 in motor behavior and balance in mice, finding that its deletion leads to specific motor deficits but not cognitive or anxiety-related issues.

bioRxiv · Feb 6, 2019Animal Behavior & Cognition