Author

L. Tortola

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:fluorescence / live-cell microscopy· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

M. Kopf· 3 shared F. Ampenberger· 2 shared A. Ochsenbein· 1 shared C. Riether· 1 shared D. Egli· 1 shared E. Rosenwald· 1 shared G. Schwank· 1 shared I. Keller· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCancer Biology

M. Kopf

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

CD4+ T cell-derived IL21 regulates stem cell fate in acute myeloid leukemia by activation of p38-MAPK signaling

V. Rubino, M. Hueppi, S. Hoepner, L. Tortola, L. Taylor, I. Keller, R. Bruggmann, M.-N. Kronig, U. V. Bacher, M. Kopf, A. Ochsenbein, C. Riether

This study identifies IL21 from CD4+ T cells as a negative regulator of leukemia stem cell self-renewal through ROS and p38-MAPK signaling, with prognostic implications in AML.

bioRxiv · Sep 1, 2023 · PreprintCancer Biology

KappaBle fluorescent reporter mice enable dynamic and low-background single-cell detection of NF-kB activity in vivo

L. Tortola, F. Ampenberger, E. Rosenwald, S. Heer, T. Ruelicke, J. Kisielow, M. Kopf

The paper develops KappaBle mice with a destabilized EGFP reporter to sensitively and dynamically monitor NF-kB activity at the single-cell level in vivo during inflammation and infection.

bioRxiv · Sep 2, 2021 · PreprintImmunology

Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing

N. Frey, L. Tortola, D. Egli, S. Janjuha, K. F. Marquart, T. Rothgangl, F. Ampenberger, M. Kopf, G. Schwank

This study identifies Rnf31 and Vps4b as factors enabling pancreatic cancer to evade T cell killing, showing their inactivation increases T cell-mediated tumor cell death.

bioRxiv · Jul 29, 2021Cancer Biology