M. Kopf

Treatment of a genetic liver disease in mice through transient prime editor expression

This paper demonstrates transient prime editor expression in mice to correct a genetic liver disease, reducing blood phenylalanine levels below the therapeutic threshold.

CD4+ T cell-derived IL21 regulates stem cell fate in acute myeloid leukemia by activation of p38-MAPK signaling

This study identifies IL21 from CD4+ T cells as a negative regulator of leukemia stem cell self-renewal through ROS and p38-MAPK signaling, with prognostic implications in AML.

Apolipoprotein E controls Dectin-1-dependent development of monocyte-derived alveolar macrophages upon pulmonary β-glucan-induced inflammatory adaptation

This study identifies Apolipoprotein E's role in Dectin-1-dependent development of monocyte-derived alveolar macrophages during pulmonary β-glucan-induced inflammation.

KappaBle fluorescent reporter mice enable dynamic and low-background single-cell detection of NF-kB activity in vivo

The paper develops KappaBle mice with a destabilized EGFP reporter to sensitively and dynamically monitor NF-kB activity at the single-cell level in vivo during inflammation and infection.

Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing

This study identifies Rnf31 and Vps4b as factors enabling pancreatic cancer to evade T cell killing, showing their inactivation increases T cell-mediated tumor cell death.

Long-term culture of fetal monocyte precursors in vitro allowing the generation of bona fide alveolar macrophages in vivo

This study demonstrates the in vitro generation of alveolar macrophage-like cells from fetal liver monocytes using GM-CSF, which can engraft in vivo and protect against respiratory infections.

High resolution profiling of MHC-II peptide presentation capacity, by Mammalian Epitope Display, reveals SARS-CoV-2 targets for CD4 T cells and mechanisms of immune-escape

The paper uses a new platform to profile MHC-II peptide presentation capacity for SARS-CoV-2, revealing immune evasion mechanisms and CD4 T cell targets.

A macrophage-pericyte axis directs tissue restoration via Amphiregulin-induced TGFβ activation

This study identifies a macrophage-pericyte axis that promotes tissue restoration through Amphiregulin-induced TGFβ activation during acute injury.