Author

J. MacRae

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

A. Andrusaite· 1 shared A. Asuaje· 1 shared A. Clear· 1 shared A. D'Avola· 1 shared A. Ghanate· 1 shared A. Gunawan· 1 shared A. Jain· 1 shared A. McKee· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

A. Andrusaite

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

GOT1 primes the cellular response to hypoxia by supporting glycolysis and HIF1α stabilisation

F. Grimm, A. Asuaje, A. Jain, M. Silva dos Santos, J. Kleinjung, P. M. Nunes, S. Gehrig, L. Fets, J. MacRae, D. Anastasiou

This study identifies GOT1 as a key factor in priming cells for hypoxic adaptation by enhancing glycolysis and HIF1α stabilization before full HIF1 activation.

bioRxiv · Sep 6, 2023 · PreprintCancer Biology

PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma

A. D'Avola, N. Legrave, M. Tajan, P. Chakravarty, R. Shearer, H. King, E. Cheung, A. Clear, A. Gunawan, L. Zhang, L. James, J. MacRae, J. Gribben, D. Calado, K. Vousden, J. Riches

This study identifies PHGDH as essential for germinal center formation and shows its inhibition reduces lymphoma progression and improves survival.

bioRxiv · Nov 11, 2021Immunology

Perturbation of the gut microbiota by antibiotics results in accelerated breast tumour growth and metabolic dysregulation

B. Kirkup, A. McKee, K. Makin, J. Paveley, S. Caim, C. Alcon-Giner, C. Leclaire, M. Dalby, G. Le Gall, A. Andrusaite, P. Kreuzaler, P. Driscoll, J. MacRae, E. Calvani, A. Ghanate, , S. D. Robinson

This study shows that antibiotics disrupt the gut microbiota, leading to faster breast tumour growth and metabolic changes in mice.

bioRxiv · Feb 19, 2019 · PreprintCancer Biology