Monocyte intrinsic NOD2 signalling inhibits pathogenic macrophage differentiation and its loss in inflammatory macrophages improves intestinal inflammation.
C. Chauvin, D. Alvarez, K. Radulovic, O. Boulard, W. Laine, M. Delacre, N. Waldschmitt, E. Segura, J. Kluza, M. Chamaillard, L. F. Poulin
This study shows that NOD2 signaling in monocytes inhibits their conversion to pathogenic macrophages and its loss worsens intestinal inflammation.
bioRxiv · Oct 6, 2022 · PreprintImmunology