A crypt-operating DNA repair checkpoint for uncoupling regeneration and tumorigenesis
Richard Ruez, K. Radulovic, JJ Martinez-Torres, Olivier Boulard, Mound. Abdallah, Thomas Paz del Socorro, Giulia Nigro, Marion Seillier, Ghaffar Muharram, JJ Martinez-Garcia, François Gerbe, Emilie Floquet, Isabelle VAN SEUNINGEN, Alice Carrier, Philippe Jay, , Mathias Chamaillard
This study identifies Nlrp6 as a regulator of DNA repair and epithelial regeneration in intestinal crypts, linking DNA damage responses to colorectal cancer progression.
bioRxiv · Mar 2, 2026 · PreprintCell Biology