Senescence-Induced Immune Remodeling Facilitates Metastatic Adrenal Cancer in a Sex-Dimorphic Manner
K. M. Warde, L. Liu, L. J. Smith, B. K. Lohman, C. J. Stubben, H. A. Ekiz, J. L. Ammer, K. Converso-Baran, T. J. Giordano, G. D. Hammer, K. J. Basham
This study shows that cellular senescence induced by ZNRF3 loss remodels the microenvironment, promoting metastatic adrenal cancer with sex-specific immune responses.
bioRxiv · Apr 29, 2022Cancer Biology