L. J. Smith

Single Cell RNA Sequencing Reveals Emergent Notochord-Derived Cell Subpopulations in the Postnatal Nucleus Pulposus

This study uses single cell RNA sequencing to identify distinct subpopulations of notochord-derived nucleus pulposus cells in postnatal mice, revealing developmental stages and molecular signatures associated with extracellular matrix production.

Senescence-Induced Immune Remodeling Facilitates Metastatic Adrenal Cancer in a Sex-Dimorphic Manner

This study shows that cellular senescence induced by ZNRF3 loss remodels the microenvironment, promoting metastatic adrenal cancer with sex-specific immune responses.

Three-dimensional drug screen identifies HDAC inhibitors as therapeutic agents in mTORC1-driven lymphangioleiomyomatosis

A 3D drug screen identified HDAC inhibitors as effective against mTORC1-driven lymphangioleiomyomatosis by reducing invasion and selectively killing TSC2-/- cells.

Comparison of porcine corneal decellularization methods and importance of preserving corneal limbus through decellularization

This study compares three porcine corneal decellularization methods and shows that preserving the limbus reduces decellularization efficiency but lessens structural damage.

Single-cell chromatin accessibility in glioblastoma delineates cancer stem cell heterogeneity predictive of survival

The paper uses single-cell chromatin accessibility to identify distinct glioblastoma stem cell states predictive of patient survival.