Author

G. D. Hammer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

T. J. Giordano· 3 shared A. M. Lerario· 2 shared D. R. Mohan· 2 shared K. Converso-Baran· 2 shared K. J. Basham· 2 shared A. A. Apfelbaum· 1 shared A. C. Latronico· 1 shared A. L. Solon· 1 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

T. J. Giordano

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Author profile →

3 papers

Recent·Most cited

Targeting oncogenic Wnt/β-catenin signaling in adrenocortical carcinoma disrupts ECM expression and impairs tumor growth.

M. K. Penny, A. M. Lerario, K. J. Basham, S. Chukkapalli, Y. Yu, D. R. Mohan, C. LaPensee, K. Converso-Baran, M. Hoenerhoff, L. Suarez Fernandez, C. Gonzalez del Rey, T. J. Giordano, R. Han, E. A. Newman, G. D. Hammer

This paper identifies a Wnt/β-catenin-regulated extracellular matrix (ECM) program in adrenocortical carcinoma (ACC) that promotes tumor growth and shows that inhibiting this pathway reduces tumor viability and growth in preclinical models.

bioRxiv · Oct 23, 2022Cancer Biology

β-catenin programs a tissue-specific epigenetic vulnerability in aggressive adrenocortical carcinoma

D. R. Mohan, K. S. Borges, I. Finco, C. R. LaPensee, J. Rege, A. L. Solon, D. W. Little, T. Else, M. Q. Almeida, D. Dang, J. Haggerty-Skeans, A. A. Apfelbaum, M. Vinco, A. Wakamatsu, B. M. P. Mariani, , G. D. Hammer

This study shows that β-catenin maintains adrenocortical carcinoma differentiation through chromatin and histone interactions, and that targeting EZH2 can disrupt this process and inhibit tumor growth.

bioRxiv · Jul 2, 2022 · PreprintCancer Biology

Senescence-Induced Immune Remodeling Facilitates Metastatic Adrenal Cancer in a Sex-Dimorphic Manner

K. M. Warde, L. Liu, L. J. Smith, B. K. Lohman, C. J. Stubben, H. A. Ekiz, J. L. Ammer, K. Converso-Baran, T. J. Giordano, G. D. Hammer, K. J. Basham

This study shows that cellular senescence induced by ZNRF3 loss remodels the microenvironment, promoting metastatic adrenal cancer with sex-specific immune responses.

bioRxiv · Apr 29, 2022Cancer Biology