Author

J. L. Heier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Research Focus:software / tool· 1

Frequent Co-Authors

L. L. Parker· 3 shared N. Widstrom· 2 shared C. J. Heier· 1 shared D. J. Boselli· 1 shared E. D. Pratt· 1 shared G. Andrianov· 1 shared H. Peterson· 1 shared J. F. Blankenhorn· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

L. L. Parker

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Author profile →

3 papers

Recent·Most cited

Antibody-free time-resolved terbium luminescence assays designed for cyclin-dependent kinase 5 (CDK5)

J. L. Heier, D. J. Boselli, L. L. Parker

The paper develops antibody-free time-resolved terbium luminescence assays for CDK5 and CDK2 using synthetic substrates with phospho-inducible motifs, enabling CDK5-specific drug discovery.

bioRxiv · Apr 24, 2024 · PreprintBiochemistry

Novel substrate prediction for the TAM family of RTKs using phosphoproteomics and structure-based modeling

N. Widstrom, G. Andrianov, J. L. Heier, C. J. Heier, J. L. Karanicolas, L. L. Parker

This paper designs synthetic peptide substrates for TAM family kinases using phosphoproteomics and AlphaFold2, showing that predicted interactions correlate with biochemical validation.

bioRxiv · Sep 1, 2023Biochemistry

Novel Bruton's Tyrosine Kinase (BTK) substrates for time-resolved luminescence assays

N. Widstrom, M. Perez, E. D. Pratt, J. L. Heier, J. F. Blankenhorn, L. Breidenbach, H. Peterson, L. L. Parker

The paper identifies novel BTK substrates and develops a pipeline to generate synthetic substrates for time-resolved luminescence assays.

bioRxiv · Apr 5, 2022Biochemistry