Author

L. L. Parker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 3 Approach:statistical model· 3 Approach:deep learning· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. L. Heier· 2 shared M. Perez· 2 shared N. Widstrom· 2 shared A. Beiser· 1 shared B. M. Noel· 1 shared C. J. Heier· 1 shared C. Navis· 1 shared D. A. Bernlohr· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiochemistry

J. L. Heier

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Author profile →

6 papers

Recent·Most cited

Novel substrate prediction for the TAM family of RTKs using phosphoproteomics and structure-based modeling

N. Widstrom, G. Andrianov, J. L. Heier, C. J. Heier, J. L. Karanicolas, L. L. Parker

This paper designs synthetic peptide substrates for TAM family kinases using phosphoproteomics and AlphaFold2, showing that predicted interactions correlate with biochemical validation.

bioRxiv · Sep 1, 2023Biochemistry

Novel Bruton's Tyrosine Kinase (BTK) substrates for time-resolved luminescence assays

N. Widstrom, M. Perez, E. D. Pratt, J. L. Heier, J. F. Blankenhorn, L. Breidenbach, H. Peterson, L. L. Parker

The paper identifies novel BTK substrates and develops a pipeline to generate synthetic substrates for time-resolved luminescence assays.

bioRxiv · Apr 5, 2022Biochemistry

A high-throughput 384-well CometChip platform reveals a role for 3-methyladenine in the cellular response to etoposide-induced DNA damage

J. Li, A. Beiser, N. B. Dey, S. Takeda, L. K. Saha, K. Hirota, L. L. Parker, M. Carter, M. I. Arrieta, R. W. Sobol

The paper develops a 384-well CometChip platform for high-throughput DNA damage analysis and identifies 3-methyladenine as an enhancer of etoposide-induced DNA damage.

bioRxiv · Mar 29, 2022Cancer Biology

Multiplexable fluorescence lifetime imaging (FLIM) probes for Abl and Src-family kinases

N. P. Damayanti, S. Jena, J. Tan, J. M. K. Irudayaraj, L. L. Parker

The paper develops and applies FLIM probes to measure Abl and Src-family kinase activities in live cells without FRET or genetic encoding.

bioRxiv · Feb 27, 2020Biochemistry

Multi-omic profiling of tyrosine kinase inhibitor-resistant K562 cells suggests metabolic reprogramming to promote cell survival

B. M. Noel, S. B. Ouellette, L. Marholz, D. M. Dickey, C. Navis, T.-Y. Yang, V. Nguyen, S. J. Parker, D. A. Bernlohr, Z. Sachs, L. L. Parker

This study identifies metabolic reprogramming and novel markers in TKI-resistant CML cells through multi-omic profiling.

bioRxiv · Jan 16, 2019 · PreprintCancer Biology

High-throughput identification of FLT3 wild-type and mutant kinase substrate preferences and application to design of sensitive in vitro kinase assay substrates

M. Perez, J. Blankenhorn, K. J. Murray, L. L. Parker

The paper identifies FLT3 kinase substrates for wild-type and mutant variants and develops sensitive in vitro assay substrates for inhibitor screening.

bioRxiv · Oct 31, 2018Biochemistry