J. L. Puetzer

Intermittent Cyclic Stretch of Engineered Ligaments Drives Hierarchical Collagen Fiber Maturation in a Dose- and Organizational-Dependent Manner

This study shows that intermittent cyclic stretch improves collagen fiber maturation in engineered ligaments, with effects dependent on strain magnitude and timing.

Enthesis Maturation in Engineered Ligaments is Differentially Driven by Loads that Mimic Slow Growth Elongation and Rapid Cyclic Muscle Movement

This study investigates how slow stretch and cyclic loading differentially drive maturation of engineered entheses, improving interface mechanics and zonal composition.

Temporal Application of Lysyl Oxidase during Hierarchical Collagen Fiber Formation Differentially Effects Mechanics in Engineered Tissues

This study evaluates the effect of LOX treatment timing on collagen fiber formation and mechanics in engineered tissues, finding that LOXL2 supplementation at 4 weeks improves crosslinking and tissue strength.

Driving Native-like Zonal Enthesis Formation in Engineered Ligaments Using Mechanical Boundary Conditions and β-Tricalcium Phosphate

This study uses mechanical boundary conditions and β-tricalcium phosphate to guide ligament fibroblasts to form zonal entheses with collagen organization and mineralization similar to immature bovine entheses.

An Inducible Model for Unraveling the Effects of Advanced Glycation End-Products in Aging Connective Tissues

This study develops a method to induce AGE accumulation in collagen gels without affecting cell viability, enabling investigation of AGE effects on tissue mechanics and cell-matrix interactions.

Driving Hierarchical Collagen Fiber Formation for Functional Tendon, Ligament, and Meniscus Replacement

This study shows that restrained cell-seeded collagen gels can produce native-sized, organized collagen fibers for tendon, ligament, and meniscus tissues in vitro.