Serine Palmitoyltransferase Controls Stemness of Intestinal Progenitors
S. A. Summers, B. Chaurasia, Y. Li, V. Kaddai, J. L. Wilkerson, J. A. Maschek, J. Cox, P. Wei, C. Bensard, P. J. Meikle, H. Clevers, J. Shayman, Y. Hirabayashi, W. L. Holland, J. Rutter
The paper shows that serine palmitoyltransferase (SPT) modulates intestinal stem cell homeostasis by promoting stemness through sphingolipid production and PPAR-alpha activation, linking diet to cancer risk.
bioRxiv · Dec 3, 2020 · PreprintCell Biology