Author

P. J. Meikle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

A. J. Murphy· 2 shared G. Pernes· 2 shared K. Huynh· 2 shared M. T. Coughlan· 2 shared N. A. Mellett· 2 shared P. K. Morgan· 2 shared T. J. Collins· 2 shared A. A. T. Smith· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

A. J. Murphy

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Efficient megakaryopoiesis and platelet production require phospholipid remodeling and PUFA uptake through CD36

M. N. Barrachina, G. Pernes, I. C. Becker, I. Allaeys, T. I. Hirsch, D. J. Groeneveld, A. O. Khan, D. Freire, K. Guo, E. Carminita, P. K. Morgan, T. J. Collins, N. Mellett, Z. Wei, I. Almazni, , K. R. Machlus

This study identifies the role of phospholipid remodeling and PUFA uptake via CD36 in megakaryopoiesis and platelet production, showing dietary fatty acids impact platelet counts.

bioRxiv · Feb 12, 2023Cell Biology

An immune cell lipid atlas reveals the basis of susceptibility to ferroptosis

G. Pernes, P. K. Morgan, K. Huynh, C. Giles, S. Paul, A. A. T. Smith, N. A. Mellett, C. Bertuzzo Veiga, T. J. Collins, T. M. De Silva, M. K. Lee, P. J. Meikle, G. I. Lancaster, A. J. Murphy

The paper characterizes immune cell lipidomes and shows how lipid composition influences susceptibility to ferroptosis.

bioRxiv · Feb 10, 2023 · PreprintCell Biology

SOD2 in Skeletal Muscle: New Insights from an Inducible Deletion Model

A. Zhuang, C. Yang, Y. Liu, Y. Tan, S. T. Bond, S. Walker, T. Sikora, A. Sharma, J. B. de Haan, P. J. Meikle, M. T. Coughlan, A. C. Calkin, B. G. Drew

This study deletes SOD2 in skeletal muscle of adult mice and finds no major metabolic impairment but altered lipid metabolism and mitochondrial abundance.

bioRxiv · May 20, 2021Physiology

Training-induced bioenergetic improvement in human skeletal muscle is associated with non-stoichiometric changes in the mitochondrial proteome without reorganization of respiratory chain content

C. Granata, N. J. Caruana, J. Botella, N. A. Jamnick, K. Huynh, J. Kuang, H. A. Janssen, B. Reljic, N. A. Mellett, A. Laskowski, T. L. Stait, A. E. Frazier, M. T. Coughlan, P. J. Meikle, D. R. Thorburn, , D. J. Bishop

The paper investigates training-induced mitochondrial adaptations in human skeletal muscle, finding non-stoichiometric changes in the proteome and challenging previous assumptions about bioenergetic improvements.

bioRxiv · Feb 19, 2021Cell Biology

Serine Palmitoyltransferase Controls Stemness of Intestinal Progenitors

S. A. Summers, B. Chaurasia, Y. Li, V. Kaddai, J. L. Wilkerson, J. A. Maschek, J. Cox, P. Wei, C. Bensard, P. J. Meikle, H. Clevers, J. Shayman, Y. Hirabayashi, W. L. Holland, J. Rutter

The paper shows that serine palmitoyltransferase (SPT) modulates intestinal stem cell homeostasis by promoting stemness through sphingolipid production and PPAR-alpha activation, linking diet to cancer risk.

bioRxiv · Dec 3, 2020 · PreprintCell Biology