Author

J. Lew

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

D. Falzarano· 3 shared V. Gerdts· 3 shared A. A. A. Kelvin· 1 shared A. Banerjee· 1 shared A. Finzi· 1 shared A. Ge· 1 shared A. J. McGeer· 1 shared A. Kroeker· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMicrobiology

D. Falzarano

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Defining the in vivo role of mTORC1 in thyrocytes by studying the TSC2 conditional knockout mouse model

C. L. Rossetti, B. Lourenconi, F. L. M. Pecanha, A. T. Franco, V. Nose, J. Lew, E. Carneiro, E. Bernal-Mizrachi, J. P. Werneck de Castro

This study uses a TSC2 conditional knockout mouse model to show that mTORC1 activation in thyrocytes inhibits thyroid hormone biosynthesis, promotes growth, and leads to thyroid tumors.

bioRxiv · Nov 1, 2023 · PreprintPhysiology

An S1 subunit vaccine and combination adjuvant (COVAC-1) elicits robust protection against SARS-CoV-2 challenge in African green monkeys

L. Garnett, K. Tran, M. Chan, K. Tierney, Z. Schiffman, J. Audet, J. Lew, C. Meilleur, M. Chan, K. Manguiat, N. Tailor, R. Vendramelli, Y. Deschambault, G. Beaudoin-Bussieres, C. Bourassa, , D. Falzarano

COVAC-1, an S1 subunit vaccine with adjuvant, protects African green monkeys from SARS-CoV-2 challenge by reducing viral load and pathology in the respiratory tract.

bioRxiv · Jun 16, 2022 · PreprintMicrobiology

Immunogenicity of convalescent and vaccinated sera against clinical isolates of ancestral SARS-CoV-2, beta, delta, and omicron variants

A. Banerjee, J. Lew, A. Kroeker, K. Baid, P. Aftanas, K. Nirmalarajah, F. Maguire, R. Kozak, R. McDonald, A. Lang, V. Gerdts, S. E. Straus, L. Gilbert, A. X. Li, M. Mozafarihasjin, , D. Falzarano

The paper assesses neutralizing antibody responses of convalescent and vaccinated sera against SARS-CoV-2 ancestral, beta, delta, and omicron variants.

bioRxiv · Jan 13, 2022Immunology

Male sex and age biases viral burden, viral shedding, and type 1 and 2 interferon responses during SARS-CoV-2 infection in ferrets

M. Francis, B. Richardson, M. McNeil, M. Rioux, M. Foley, A. Ge, R. Pechous, J. Kindrachuk, C. Cameron, C. Richardson, J. Lew, M. Cameron, V. Gerdts, D. Falzarano, A. A. A. Kelvin

This study shows that male sex and age in ferrets affect viral burden, shedding, and interferon responses during SARS-CoV-2 infection, with older males showing delayed antiviral responses.

bioRxiv · Jan 12, 2021Microbiology