Platelet C5aR1 Aggravates Myocardial Infarction through Platelet-Neutrophil Interactions and CXCL4-Dependent NET Release
Henry Nording, Lasse Baron, Manuela Sauter, Lara Hagemann, Jacob von Esebeck, Nicolas Schommer, Daniel Duerschmied, Jens Uwe Marquardt, Carolin Lerchenmüller, Christine Zürn, Iris-Sofia Bibli, Hellmut G. Augustin, J. Müller Oliver, Harald F. Langer
This study shows that platelet C5aR1 worsens myocardial infarction by promoting neutrophil activation and NET release, and that targeting it can reduce cardiac damage.
bioRxiv · Jun 18, 2026 · PreprintImmunology