Platelet C5aR1 mediates sex-specific ischemia-driven revascularization through estradiol-dependent CXCL4 release
Henry Nording, Lasse Baron, Manuela Sauter, Lara Hagemann, Jacob von Esebeck, Nicolas Schommer, Daniel Duerschmied, Jens Uwe Marquardt, Carolin Lerchenmüller, Christine S. Zuern, Iris-Sofia Bibli, Hellmut G. Augustin, Oliver J Mueller, Harald F. Langer
This study identifies a sex-specific mechanism where platelet C5aR1 mediates ischemia-driven revascularization through estradiol-dependent CXCL4 release, explaining sex differences in cardiovascular outcomes.
bioRxiv · Jun 27, 2026 · PreprintImmunology