Author

J. M. A. Grime

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

G. A. Voth· 3 shared A. J. Pak· 2 shared A. E. P. Durumeric· 1 shared A. K. Chen· 1 shared A. Srivastava· 1 shared A. Yu· 1 shared J. A. G. Briggs· 1 shared J. J. Madsen· 1 shared

Activity by Year

2017-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersBiophysics

G. A. Voth

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3 papers

Recent·Most cited

Supercharged Assembly: A Broad-Spectrum Mechanism of Action for Drugs that Undermine Controlled HIV-1 Viral Capsid Formation

A. J. Pak, J. M. A. Grime, A. Yu, G. A. Voth

This study uses molecular dynamics simulations to show how capsid inhibitors disrupt HIV-1 capsid assembly, leading to structural defects and disassembly, and highlights the importance of dynamic mechanisms in drug design.

bioRxiv · Mar 1, 2019Biophysics

Entropic Forces Drive Clustering and Spatial Localization of Influenza A M2 During Viral Budding

J. J. Madsen, J. M. A. Grime, J. S. Rossman, G. A. Voth

This paper shows that entropic forces drive M2 protein clustering and spatial localization during influenza viral budding, contributing to membrane curvature and scission.

bioRxiv · Jul 11, 2018Biophysics

Immature HIV-1 Lattice Assembly Dynamics are Regulated by Scaffolding from Nucleic Acid and the Plasma Membrane

A. J. Pak, J. M. A. Grime, P. Sengupta, A. K. Chen, A. E. P. Durumeric, A. Srivastava, M. Yeager, J. A. G. Briggs, J. Lippincott-Schwartz, G. A. Voth

This study investigates how HIV-1 Gag polyprotein assembly is regulated by RNA and the plasma membrane using computational and experimental methods, revealing scaffolding roles for these components.

bioRxiv · Jul 13, 2017Biophysics