J. J. Madsen

Dynamic Nature of Staphylococcus aureus Type I Signal Peptidases

This study uses molecular dynamics simulations to analyze the dynamic behavior of S. aureus Type I signal peptidases SpsA and SpsB, including the impact of the P29S mutation on their structure and function.

Evaluating polarizable biomembrane simulations against experiments

This study evaluates polarizable lipid force fields against experimental data and finds non-polarizable models often perform better despite higher computational cost.

Elucidating the complex membrane binding of a protein with multiple anchoring domains

This study uses molecular dynamics simulations to investigate how FVa binds to lipid membranes, revealing orientation changes and domain reorganization that influence its interaction with specific lipids.

Staphylococcus aureus FtsZ and PBP4 bind to the conformationally dynamic N-terminal domain of GpsB

This study determines the structure of S. aureus GpsB's N-terminal domain, revealing its interaction with FtsZ and PBP4, and shows its essential role in cell division.

Entropic Forces Drive Clustering and Spatial Localization of Influenza A M2 During Viral Budding

This paper shows that entropic forces drive M2 protein clustering and spatial localization during influenza viral budding, contributing to membrane curvature and scission.