J. A. G. Briggs

This study uses molecular dynamics simulations to analyze how HIV-1 matrix protein interactions with lipids change during viral maturation, identifying altered binding modes of PIP2 lipids.

This study uses cryo-EM to determine high-resolution structures of HIV-1 capsid lattices containing hexamers and pentamers, revealing the role of IP6 in pentamer formation and the structure of the lattice bound to the drug GS-6207.

This study identifies two structural switches in HIV-1 capsid protein that modulate host factor binding based on capsid curvature and oligomerization state.

This study engineers a SARS-CoV-2 spike protein with a disulfide bond to stabilize the locked conformation, revealing structural dynamics and the role of domain D in conformational changes and viral fitness.

The paper shows FCHO primes AP2 for clathrin-coated vesicle incorporation, triggering FCHO release to enable further AP2 activation and recruitment.

This study uses molecular dynamics simulations and cryo-ET to show HIV-1 capsids exhibit strain patterns and rupture via crack propagation along high-strain regions.

This study determines the structure of HIV-1 matrix (MA) in immature and mature virions, revealing a hexameric lattice formed during maturation that repurposes the membrane for viral entry.

This study uses coarse-grained models and cryo-ET data to show that SARS-CoV-2 spike trimers cooperatively bind to ACE2 dimers, promoting S1 dissociation and exposing the fusion machinery.

This study evaluates closed-state SARS-CoV-2 spike protein immunization in mice, finding it induces potent neutralizing antibodies and T-cell responses, with unique binding properties compared to standard S protein constructs.

This paper investigates the structure and dynamics of immature HIV-1 Gag lattice edges, revealing partial hexamers and their role in proteolytic maturation.

This study uses cryo-electron microscopy to determine the structure, conformational flexibility, and distribution of SARS-CoV-2 spike protein trimers on intact virions.

This study determines the structure of assembled influenza A virus matrix protein M1 and reveals how it oligomerizes to mediate virion assembly and disassembly.

This paper designs a thermostable, closed SARS-CoV-2 spike protein trimer that remains in the pre-fusion state and can be used in serological assays.

The paper introduces a method using fluorescent barcoding and electron microscopy to enable high-throughput screening of ultrastructural phenotypes in yeast.

This paper demonstrates the use of cryo-CLEM with fluorescence autoquenching to detect membrane fusion states between influenza virus-like particles and lipid vesicles.

This study investigates how actin network components contribute to endocytic membrane bending and vesicle formation in yeast using genetic mutants and hybrid imaging.

This study investigates how HIV-1 Gag polyprotein assembly is regulated by RNA and the plasma membrane using computational and experimental methods, revealing scaffolding roles for these components.