Author

J. M. Ames

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Oberst· 2 shared D. Shukla· 2 shared T. Yadavalli· 2 shared A. Agelidis· 1 shared B. P. Daniels· 1 shared C. D. Patil· 1 shared C. Patil· 1 shared G. T. Norris· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

A. Oberst

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

RIPK3 coordinates RHIM domain-dependent inflammatory transcription in neurons

S. B. Kofman, L. H. Chu, J. M. Ames, S. D. Chavarria, K. Lichauco, B. P. Daniels, A. Oberst

This study shows RIPK3 drives antiviral transcription in neurons during ZIKV infection, while inducing cell death in MEFs, with RHIM domain interactions mediating these context-dependent functions.

bioRxiv · Feb 29, 2024 · PreprintImmunology

Oligodendrocyte-derived IL-33 functions as a microglial survival factor during neuroinvasive flavivirus infection

G. T. Norris, J. M. Ames, S. F. Ziegler, A. Oberst

This paper identifies IL-33 as a critical factor for microglial survival during neuroinvasive flavivirus infection, showing it promotes CNS tolerance without affecting viral clearance or adaptive immunity.

PLOS Pathogens · Nov 20, 2023Peer-reviewedImmunology

OPTN limits herpes stromal keratitis severity and demyelination through negative regulation of IL-17 and hyperinflammatory T-cell response

J. M. Ames, T. Yadavalli, C. Patil, J. Hopkins, I. Bhattacharya, D. Shukla

The paper investigates how OPTN reduces HSV-1-induced HSK severity and demyelination by suppressing IL-17 and hyperinflammatory T-cell responses in a mouse model.

bioRxiv · Nov 29, 2021 · PreprintImmunology

mTORC2 combats cellular stress and potentiates immunity during viral infection

R. K. Suryawanshi, C. D. Patil, A. Agelidis, R. Koganti, J. M. Ames, L. Koujah, T. Yadavalli, K. Madavaraju, L. M. Shantz, D. Shukla

This study shows mTORC2 is essential for host survival during HSV-1 infection by enhancing immunity and reducing cell death.

bioRxiv · Oct 9, 2020 · PreprintCell Biology