Author

J. Hopkins

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

D. Shukla· 3 shared T. Yadavalli· 3 shared A. Agelidis· 2 shared A. Campeau· 1 shared B. A. Turturice· 1 shared C. Christodoulidou· 1 shared C. D. Patil· 1 shared C. Georgiou· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersImmunology

D. Shukla

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structure and mechanism of LARGE1 matriglycan polymerase

S. Joseph, N. J. Schnicker, Z. Xu, T. Yang, J. Hopkins, M. Watkins, S. Chakravarthy, O. Davulcu, M. E. Anderson, D. Venzke, K. P. Campbell

The paper determines the cryo-EM structure of LARGE1 and shows it functions as a dimer to processively polymerize matriglycan on dystroglycan using alternating active sites.

bioRxiv · May 12, 2022Biochemistry

OPTN limits herpes stromal keratitis severity and demyelination through negative regulation of IL-17 and hyperinflammatory T-cell response

J. M. Ames, T. Yadavalli, C. Patil, J. Hopkins, I. Bhattacharya, D. Shukla

The paper investigates how OPTN reduces HSV-1-induced HSK severity and demyelination by suppressing IL-17 and hyperinflammatory T-cell responses in a mouse model.

bioRxiv · Nov 29, 2021 · PreprintImmunology

Dynamic regulation of hierarchical heterogeneity in Acute Myeloid Leukemia serves as a tumor immunoevasion mechanism

C. Pospori, W. Grey, S. Gonzalez-Anton, S. V. Gibson, C. Georgiou, F. Birch, G. Stevens, T. Williams, R. Khorshed, M. L. R. Haltalli, M.-N. Skoufou-Papoutsaki, K. Sloan, H. H. Encabo, J. Hopkins, C. Christodoulidou, , C. L. Lo Celso

The paper shows that hierarchical heterogeneity in AML cells, regulated by immune responses, contributes to disease progression through PDL1 upregulation and dynamic balance between proliferation and immunosuppression.

bioRxiv · Dec 21, 2020 · PreprintCancer Biology

Disruption of innate defense responses by endoglycosidase HPSE promotes cell survival

A. Agelidis, B. A. Turturice, R. K. Suryawanshi, T. Yadavalli, D. Jaishankar, J. Ames, J. Hopkins, L. Koujah, C. D. Patil, S. R. Hadigal, E. J. Kyzar, A. Campeau, J. M. Wozniak, D. J. Gonzalez, I. Vlodavsky, , D. Shukla

This study shows that HPSE disrupts innate defense responses, promoting cell survival during HSV-1 infection by inhibiting cell-intrinsic defenses and facilitating host cell reprogramming.

bioRxiv · Aug 5, 2020Cell Biology

The spread of chloramphenicol-resistant Neisseria meningitidis in Southeast Asia

E. M. Batty, T.-P. Cusack, J. Thaipadungpanit, W. Watthanaworawit, V. Carrara, S. Sihalath, J. Hopkins, S. Soeng, C. Ling, P. Turner, D. A. B. Dance

This study reports the spread of chloramphenicol-resistant Neisseria meningitidis across Southeast Asia using whole-genome sequencing of isolates from Cambodia, Thailand, and Laos.

bioRxiv · Dec 13, 2019Microbiology

Host Enzymes Heparanase and Cathepsin L Promote Herpes Simplex Virus-2 Release from Cells

J. Hopkins, T. Yadavalli, A. Agelidis, D. Shukla

This study identifies heparanase and cathepsin L as host enzymes that facilitate HSV-2 release from cells through heparan sulfate shedding and transcriptional regulation.

bioRxiv · Jul 8, 2018Microbiology