J. M. Chacon

Mutualism reduces the severity of gene disruptions in predictable ways across microbial communities.

The paper shows mutualism reduces mutation severity in microbial communities, while competition does not, and predicts mutant fitness in complex communities by averaging simpler ones.

Phage cocktail strategies for the suppression of a pathogen in a cross-feeding coculture

This paper uses experiments and simulations to show that targeting both cross-feeding bacteria in a phage cocktail more effectively suppresses a pathogen than targeting only the pathogen.

Increasing growth rate slows adaptation when genotypes compete for diffusing resources

The paper shows that increasing growth rate slows adaptation in structured environments by causing more localized competition and reducing the effectiveness of beneficial mutations.

Cross-feeding modulates the rate and mechanism of antibiotic resistance evolution in a model microbial community of Escherichia coli and Salmonella enterica

This study shows that obligate cross-feeding in microbial communities slows antibiotic resistance evolution and alters resistance mechanisms, particularly in Escherichia coli and Salmonella enterica co-cultures.

Genome-wide assessment of Mycobacterium tuberculosis conditionally essential metabolic pathways

This study identifies conditionally essential metabolic pathways in Mycobacterium tuberculosis using Tn-seq and in silico models, revealing gaps in current knowledge of its metabolic capabilities.

A shared limiting resource leads to competitive exclusion in a cross-feeding system

The paper shows that adding a nutrient to a cross-feeding bacterial system can shift interactions from mutualism to commensalism or parasitism, affecting coexistence based on nutrient metabolism and growth rates.