R. C. Hunter

Mutualism reduces the severity of gene disruptions in predictable ways across microbial communities.

The paper shows mutualism reduces mutation severity in microbial communities, while competition does not, and predicts mutant fitness in complex communities by averaging simpler ones.

Evaluation of Expanded 2-Aminobenzothiazole Library for Inhibition of Pseudomonas aeruginosa Virulence Phenotypes

The paper evaluates a library of 2-aminobenzothiazole compounds targeting the CA domain of histidine kinases, finding they reduce virulence in Pseudomonas aeruginosa.

Outside-in: intracellular vesicles in giant sulfur bacteria contain peptidoglycan

The paper reports the presence of intracellular vesicles containing peptidoglycan and outer membrane in giant sulfur bacteria, challenging the traditional view of bacterial cell envelopes.

Staphylococcus aureus overcomes anaerobe-derived short-chain fatty acid stress via FadX and the CodY regulon

This paper shows that S. aureus uses FadX and the CodY regulon to resist short-chain fatty acid stress from anaerobic bacteria in CRS.

Dual oxic-anoxic co-culture enables direct study of host-anaerobe interactions at the airway epithelial interface

The paper introduces a dual oxic-anoxic co-culture system to study host-anaerobe interactions in airway epithelial cells and shows its utility in revealing mucus degradation and transcriptional responses to anaerobe infection.

Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium

This study investigates SARS-CoV-2 tropism, antiviral responses, and therapy effectiveness in human airway epithelium using single-cell RNA-sequencing and flow cytometry.

A putative enoyl-CoA hydratase contributes to biofilm formation and the antibiotic tolerance of Achromobacter xylosoxidans

This study identifies a putative enoyl-CoA hydratase involved in biofilm formation and antibiotic tolerance in Achromobacter xylosoxidans using a transposon mutagenesis approach.

Bioorthogonal non-canonical amino acid tagging reveals translationally active subpopulations of the cystic fibrosis lung microbiota

The paper uses BONCAT to identify translationally active bacterial subpopulations in CF lung microbiota, finding only 12-18% of cells are actively translating.

Refinement of metabolite detection in cystic fibrosis sputum reveals heme negatively correlates with lung function

The paper revisits metabolite analysis in cystic fibrosis sputum, correcting previous phenazine identifications and finding heme negatively correlates with lung function.

Agmatine accumulation by Pseudomonas aeruginosa clinical isolates confers antibiotic tolerance and dampens host inflammation.

This study shows that Pseudomonas aeruginosa clinical isolates hyperproducing agmatine gain antibiotic tolerance and reduce host inflammation in CF airways.

Cross-feeding modulates antibiotic tolerance in bacterial communities

The paper investigates how cross-feeding between bacterial species affects antibiotic tolerance, finding that MICs drop to the weakest link's level in some cases but show deviations due to growth timing and cross-protection.

16S rRNA Gene Sequencing Reveals Site-Specific Signatures Of The Upper And Lower Airways Of Cystic Fibrosis Patients

This study compares the microbiomes of sinus mucus and lung sputum from CF patients, finding distinct community structures and functional profiles between upper and lower airways.

Genome-wide survey of Pseudomonas aeruginosa PA14 reveals a role for the glyoxylate pathway and extracellular proteases in the limited utilization of mucin

This study identifies genes in Pseudomonas aeruginosa essential for mucin utilization, highlighting the glyoxylate pathway and proteases like LasB and AprA.