Author

J. M. Gottwein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3

Frequent Co-Authors

J. Bukh· 3 shared L. V. Pham· 3 shared S. Ramirez· 3 shared U. Fahnoe· 3 shared A. Offersgaard· 2 shared C. Fernandez-Antunez· 2 shared K. A. Gammeltoft· 2 shared L. A. Ryberg· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

J. Bukh

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Author profile →

3 papers

Recent·Most cited

Nirmatrelvir Resistant SARS-CoV-2 Variants with High Fitness in Vitro

Y. Zhou, K. A. Gammeltoft, L. A. Ryberg, L. V. Pham, U. Fahnoe, A. Binderup, C. R. D. Hernandez, A. Offersgaard, C. Fernandez-Antunez, G. H. J. Peters, S. Ramirez, J. Bukh, J. M. Gottwein

This study identifies nirmatrelvir-resistant SARS-CoV-2 variants with high in vitro fitness and shows that remdesivir remains effective against them.

bioRxiv · Jun 6, 2022Microbiology

Hepatitis C Virus Protease Inhibitors Show Differential Efficacy and Interactions with Remdesivir for Treatment of SARS-CoV-2 in Vitro

K. A. Gammeltoft, Y. Zhou, A. Galli, A. Offersgaard, L. V. Pham, U. Fahnoe, S. Feng, S. Ramirez, J. Bukh, J. M. Gottwein

This study evaluates the efficacy of HCV protease inhibitors against SARS-CoV-2 and their interactions with remdesivir, finding simeprevir shows synergism and is the most promising for future antiviral treatments.

bioRxiv · Dec 2, 2020Microbiology

Efficient culture of SARS-CoV-2 in human hepatoma cells enhances viability of the virus in human lung cancer cell lines permitting the screening of antiviral compounds

S. Ramirez, C. Fernandez-Antunez, L. V. Pham, L. A. Ryberg, S. Feng, M. S. Pedersen, L. S. Mikkelsen, S. Belouzard, J. Dubuisson, J. M. Gottwein, U. Fahnoe, J. Bukh

This paper adapts SARS-CoV-2 to replicate more efficiently in human cells, enabling antiviral compound screening across multiple cell lines.

bioRxiv · Oct 4, 2020 · PreprintMicrobiology