S. Belouzard

Major Metabolites From Hypericum perforatum L., Hyperforin And Hypericin, Are Both Active Against Human Coronaviruses

This study shows that hyperforin from Hypericum perforatum inhibits multiple coronaviruses, including SARS-CoV-2, with antiviral activity confirmed in human cells and potential for combination therapy with remdesivir.

Direct pharmacological AMPK activation inhibits mucosal SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy flux and the type I IFN response

This paper shows that MK-8722, a direct AMPK activator, inhibits SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy, and enhancing type I IFN response, even when applied post-exposure.

CGRP inhibits SARS-CoV-2 infection of bronchial epithelial cells and its pulmonary levels correlate with viral clearance in critical COVID-19 patients

A photoactivable natural product with broad antiviral activity against enveloped viruses including highly pathogenic coronaviruses

This paper identifies pheophorbide a as a light-activated natural antiviral effective against SARS-CoV-2, MERS-CoV, and other enveloped viruses by inhibiting viral entry and replication.

Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice

This paper identifies clofoctol as an antiviral against SARS-CoV-2, showing it inhibits viral replication and reduces lung pathology in mice.

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal coronaviruses

The paper performs bidirectional CRISPR screens to identify host factors regulating SARS-CoV-2, MERS-CoV, and seasonal coronaviruses, revealing new anti-viral proteins and general coronavirus cofactors.

Efficient culture of SARS-CoV-2 in human hepatoma cells enhances viability of the virus in human lung cancer cell lines permitting the screening of antiviral compounds

This paper adapts SARS-CoV-2 to replicate more efficiently in human cells, enabling antiviral compound screening across multiple cell lines.