Author

J. M. Irimia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Approach:experimental assay· 4 Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

P. T. Fueger· 4 shared E. Bloom-Saldana· 3 shared B. M. Bauer· 2 shared A. Castillo· 1 shared A. D. Cherrington· 1 shared B. Farmer· 1 shared C. J. Ramnanan· 1 shared D. S. Edgerton· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersPhysiology

P. T. Fueger

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Author profile →

5 papers

Recent·Most cited

Integration of metabolic flux with hepatic glucagon signaling and gene expression profiles in the conscious dog

K. C. Coate, C. J. Ramnanan, M. Smith, J. J. Winnick, G. Kraft, J. M. Irimia, B. Farmer, P. Donahue, P. J. Roach, A. D. Cherrington, D. S. Edgerton

This study examines how glucagon affects hepatic glucose production and gene expression in conscious dogs over time, revealing transient metabolic flux changes and gene regulation patterns.

bioRxiv · Sep 28, 2023Physiology

Longitudinal analysis of a dietary mouse model of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH)

M. M. Saenz, J. C. McDonough, E. Bloom-Saldana, J. M. Irimia, E. L. Cauble, A. Castillo, P. T. Fueger, L. S. Trevino

This study tracks histopathological, biochemical, transcriptomic, and microbiome changes in mice fed a NASH-promoting diet over 30 weeks, revealing progressive NAFLD development and immune/xenobiotic gene expression changes.

bioRxiv · May 19, 2023 · PreprintPhysiology

Dose-dependent progression of multiple low dose streptozotocin-induced diabetes in mice

B. M. Bauer, S. Bhattacharya, E. Bloom-Saldana, J. M. Irimia, P. T. Fueger

This study compares the effects of two low-dose streptozotocin regimens in mice, showing distinct glucose tolerance, beta cell function, and transcriptional changes.

bioRxiv · Apr 8, 2023Physiology

Pancreatic loss of Mig6 alters murine endocrine cell fate and protects functional beta cell mass in an STZ-induced model of diabetes

B. M. Bauer, J. M. Irimia, E. Bloom-Saldana, J.-W. Jeong, P. T. Fueger

This study shows that pancreatic loss of Mig6 increases beta cell mass and improves glucose tolerance in a diabetes model, but beta cell-specific loss of Mig6 does not provide similar protection.

bioRxiv · Apr 7, 2023 · PreprintPhysiology

The adaptor protein NumbL is involved in the control of glucolipotoxicity-induced pancreatic beta cell apoptosis

H. D. Basavarajappa, J. M. Irimia, P. T. Fueger

This study identifies NumbL as a mediator of glucolipotoxicity-induced beta cell apoptosis by interacting with Mig6 and TRAF6 to activate NF-κB signaling.

bioRxiv · Aug 16, 2020Biochemistry