Author

K. C. Coate

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

A. C. Powers· 2 shared C. Dai· 2 shared R. Jenkins· 2 shared A. Bradley· 1 shared A. D. Attie· 1 shared A. D. Cherrington· 1 shared A. Morgan· 1 shared B. Farmer· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPhysiology

A. C. Powers

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3 papers

Recent·Most cited

Integration of metabolic flux with hepatic glucagon signaling and gene expression profiles in the conscious dog

K. C. Coate, C. J. Ramnanan, M. Smith, J. J. Winnick, G. Kraft, J. M. Irimia, B. Farmer, P. Donahue, P. J. Roach, A. D. Cherrington, D. S. Edgerton

This study examines how glucagon affects hepatic glucose production and gene expression in conscious dogs over time, revealing transient metabolic flux changes and gene regulation patterns.

bioRxiv · Sep 28, 2023Physiology

Pancreatic islet α cell function and proliferation requires the arginine transporter SLC7A2

E. Spears, J. E. Stanley, M. Shou, C. Dai, A. Bradley, L. Yin, X. Li, K. Sellick, G. Poffenberger, K. C. Coate, S. D. Shrestha, R. Jenkins, K. Sloop, K. T. Wilson, A. D. Attie, , E. D. Dean

This study identifies SLC7A2 as essential for α cell proliferation and glucagon secretion, linking arginine transport to metabolic regulation and HbA1c variation.

bioRxiv · Aug 10, 2023Physiology

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Pancreas but are Not Enriched in Islet Endocrine Cells

K. C. Coate, J. Cha, S. Shrestha, W. Wang, L. M. Goncalves, J. Almaca, M. E. Kapp, M. Fasolino, A. Morgan, C. Dai, D. C. Saunders, R. Bottino, R. Aramandla, R. Jenkins, R. Stein, , A. C. Powers

The paper examines ACE2 and TMPRSS2 expression in the human pancreas and finds they are not enriched in islet endocrine cells, suggesting SARS-CoV-2 may not directly infect beta cells through these proteins.

bioRxiv · Aug 31, 2020 · PreprintCell Biology