Author

J. M. Jacobson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 5 Approach:experimental assay· 3 Organism:human· 3 Approach:deep learning· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Assay:proteomics· 2 Research Focus:variant calling· 2

Frequent Co-Authors

P. Chatterjee· 5 shared N. Jakimo· 3 shared M. Ponnapati· 2 shared A. Landay· 1 shared A. R. Goldman· 1 shared C. S. Palmer· 1 shared H. Y. Tang· 1 shared J. Li· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersBioengineering

P. Chatterjee

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Sub-Picomolar Detection of SARS-CoV-2 RBD via Computationally-Optimized Peptide Beacons

S. P. Tripathy, M. Ponnapati, J. M. Jacobson, P. Chatterjee

This paper designs peptide beacons using deep learning to detect SARS-CoV-2 RBD with sub-picomolar sensitivity, enabling rapid diagnostic applications.

bioRxiv · Jun 4, 2021 · PreprintBioengineering

Non-Invasive Plasma Glycomic and Metabolic Biomarkers of Post-treatment Control of HIV

L. B. Giron, C. S. Palmer, X. Yin, P. Emmanouil, M. Damra, A. R. Goldman, H. Y. Tang, R. Johnston, K. Mounzer, J. R. Kostman, P. Tebas, A. Landay, L. J. Montaner, J. M. Jacobson, J. Li, M. Abdel-Mohsen

This study identifies non-invasive plasma glycomic and metabolic biomarkers that predict viral rebound after HIV treatment interruption with high accuracy.

bioRxiv · Nov 11, 2020Microbiology

Targeted Intracellular Degradation of SARS-CoV-2 RBD via Computationally-Optimized Peptide Fusions

P. Chatterjee, M. Ponnapati, J. M. Jacobson

This study designs ACE2-derived peptides to target and degrade SARS-CoV-2 RBD via E3 ubiquitin ligases, showing effective RBD degradation in human cells.

bioRxiv · Jun 1, 2020Bioengineering

Robust Genome Editing of Single-Base PAM Targets with Engineered ScCas9 Variants

P. Chatterjee, N. Jakimo, J. M. Jacobson

This study engineers ScCas9 variants to enable robust genome editing at single-base PAM targets with improved activity and fidelity.

bioRxiv · Apr 26, 2019 · PreprintBioengineering

A Cas9 with Complete PAM Recognition for Adenine Dinucleotides

N. Jakimo, P. Chatterjee, L. Nip, J. M. Jacobson

This paper identifies a Cas9 variant with expanded PAM recognition for adenine dinucleotides, enabling broader gene editing capabilities in human cells.

bioRxiv · Sep 27, 2018Bioengineering

Divergent PAM Specificity of a Highly-Similar SpCas9 Ortholog

P. Chatterjee, N. Jakimo, J. M. Jacobson

This study characterizes the PAM specificity of ScCas9, a Cas9 ortholog from Streptococcus canis, showing divergent PAM affinity and developing a bioinformatics pipeline to explore microbial PAM diversity.

bioRxiv · Feb 2, 2018Microbiology