A. R. Goldman

Steric-free bioorthogonal profiling of cellular acetylation and glycosylation via a fluorine-selenol displacement reaction (FSeDR)

This paper introduces a fluorine-selenol displacement reaction (FSeDR) to label and image acetylation and glycosylation, and uses it with SILAC proteomics to profile acetylation substrates in prostate cancer cells.

Markers of Fungal Translocation Are Elevated During Post-Acute Sequelae of SARS-CoV-2 Infection and Induce NF-κB Triggered Inflammation.

This study identifies elevated fungal translocation markers in PASC patients, which induce NF-κB inflammation through Dectin-1 signaling.

Selective abrogation of S6K2 maps lipid homeostasis as a survival vulnerability in MAPKi-resistant NRASmut melanoma

This study identifies S6K2 as a vulnerability in MAPK inhibitor-resistant NRAS-mutant melanoma, showing its abrogation disrupts lipid homeostasis and triggers cell death.

Glycolysis downregulation is a hallmark of HIV-1 latency and sensitizes infected cells to oxidative stress

The paper shows that glycolysis downregulation is a hallmark of HIV-1 latency and that targeting antioxidant pathways can reactivate latent HIV-1.

Non-Invasive Plasma Glycomic and Metabolic Biomarkers of Post-treatment Control of HIV

This study identifies non-invasive plasma glycomic and metabolic biomarkers that predict viral rebound after HIV treatment interruption with high accuracy.

Steric-Free Bioorthogonal Labeling of Acetylation Substrates Based on a Fluorine-Thiol Displacement Reaction (FTDR)

This paper introduces a novel bioorthogonal reaction, FTDR, for selectively labeling acetylation substrates using fluorine-thiol displacement, enabling detection and imaging of acetylated proteins.