Author

J. M. Knapp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

S. L. Schreiber· 2 shared A. G. Reidenbach· 1 shared A. M. E. Faust· 1 shared B. I. C. Tresco· 1 shared B. K. Hua· 1 shared B. Melillo· 1 shared C. E. Dumelin· 1 shared C. J. Gerry· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

S. L. Schreiber

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2 papers

Recent·Most cited

Highly specific intracellular ubiquitination of a small molecule

W. Li, E. M. Garcia-Rivera, D. C. Mitchell, J. M. Chick, M. Maetani, J. M. Knapp, G. M. Matthews, R. Shirasaki, R. de Matos Simoes, V. Viswanathan, J. L. Pulice, M. G. Rees, J. A. Roth, S. P. Gygi, C. S. Mitsiades, , J. M. L. Ostrem

The paper identifies a small molecule, BRD1732, that is ubiquitinated in cells, leading to proteasome inhibition through accumulation of ubiquitin chains.

bioRxiv · Jan 26, 2024Biochemistry

Diversity-oriented synthesis encoded by deoxyoligonucleotides

L. Hudson, J. W. Mason, M. V. Westphal, M. J. R. Richter, J. R. Thielman, B. K. Hua, C. J. Gerry, G. Xia, H. L. Osswald, J. M. Knapp, Z. Y. Tan, P. Kokkonda, B. I. C. Tresco, S. Liu, A. G. Reidenbach, , K. Briner

The paper describes the design, synthesis, and validation of a 3.7 million-member DNA-encoded library using diversity-oriented synthesis to enhance structural diversity for drug discovery.

bioRxiv · Oct 16, 2022Biochemistry