Author

P. Kokkonda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 2 Approach:deep learning· 1

Frequent Co-Authors

A. Choudhary· 2 shared V. Sreekanth· 2 shared A. Deb· 1 shared A. G. Reidenbach· 1 shared A. M. E. Faust· 1 shared A. Sadagopan· 1 shared B. I. C. Tresco· 1 shared B. K. Hua· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiochemistry

A. Choudhary

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Author profile →

3 papers

Recent·Most cited

Photoswitchable Molecular Glues Enable Optical Control of Transcription Factor Degradation

C. J. Arp, M. Reynders, V. Sreekanth, P. Kokkonda, M. Pagano, A. Choudhary, D. Trauner

This paper introduces PHOIMiDs, photoswitchable immunomodulatory drugs that degrade Ikaros and Aiolos in a light-dependent manner with high selectivity.

bioRxiv · Apr 9, 2023 · PreprintBiochemistry

Diversity-oriented synthesis encoded by deoxyoligonucleotides

L. Hudson, J. W. Mason, M. V. Westphal, M. J. R. Richter, J. R. Thielman, B. K. Hua, C. J. Gerry, G. Xia, H. L. Osswald, J. M. Knapp, Z. Y. Tan, P. Kokkonda, B. I. C. Tresco, S. Liu, A. G. Reidenbach, , K. Briner

The paper describes the design, synthesis, and validation of a 3.7 million-member DNA-encoded library using diversity-oriented synthesis to enhance structural diversity for drug discovery.

bioRxiv · Oct 16, 2022Biochemistry

Proteolysis Targeting Chimeras With Reduced Off-targets

T. M. Nguyen, V. Sreekanth, A. Deb, P. Kokkonda, P. K. Tiwari, K. A. Donovan, V. M. Shoba, S. K. Chaudhary, J. A. M. Mercer, S. Lai, A. Sadagopan, M. Jan, E. S. Fischer, D. R. Liu, B. L. Ebert, A. Choudhary

This study develops a platform to identify off-target degradation of ZF proteins by PROTACs and identifies design rules to reduce off-target effects using pomalidomide analogs.

bioRxiv · Nov 18, 2021Pharmacology & Toxicology