Author

J. M. Chick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

A. Parker· 1 shared A. Wong· 1 shared B. D. Horning· 1 shared B. F. Cravatt· 1 shared C. Kadoch· 1 shared C. L. Eissler· 1 shared C. S. Mitsiades· 1 shared D. C. Mitchell· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Parker

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Author profile →

2 papers

Recent·Most cited

Highly specific intracellular ubiquitination of a small molecule

W. Li, E. M. Garcia-Rivera, D. C. Mitchell, J. M. Chick, M. Maetani, J. M. Knapp, G. M. Matthews, R. Shirasaki, R. de Matos Simoes, V. Viswanathan, J. L. Pulice, M. G. Rees, J. A. Roth, S. P. Gygi, C. S. Mitsiades, , J. M. L. Ostrem

The paper identifies a small molecule, BRD1732, that is ubiquitinated in cells, leading to proteasome inhibition through accumulation of ubiquitin chains.

bioRxiv · Jan 26, 2024Biochemistry

Selective inhibitors of JAK1 targeting a subtype-restricted allosteric cysteine

M. E. Kavanagh, B. D. Horning, R. Khattri, N. Roy, J. P. Lu, L. R. Whitby, J. C. Brannon, A. Parker, J. M. Chick, C. L. Eissler, A. Wong, J. L. Rodriguez, S. Rodiles, K. Masuda, J. R. Teijaro, , B. F. Cravatt

This study identifies an allosteric cysteine in JAK1 and TYK2, develops inhibitors targeting it, and shows high subtype selectivity with minimal off-target effects.

bioRxiv · Jan 31, 2022 · PreprintPharmacology & Toxicology